Serveur d'exploration sur le nickel au Maghreb

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Cyclization of Oxindolic methylketones with acid : A rapid synthesis of (±)-aspidofractinine

Identifieur interne : 001262 ( Main/Exploration ); précédent : 001261; suivant : 001263

Cyclization of Oxindolic methylketones with acid : A rapid synthesis of (±)-aspidofractinine

Auteurs : Dominique Cartier [France] ; Mohammed Ouahrani [France] ; Jean Lévy [France]

Source :

RBID : ISTEX:AE1758A64AFDC07FBAE4C9F16C14BA3E63B1D799

Abstract

The oxindolic methylketone 7 was cyclized in one step to the hexacyclic ketolactam 9 with acid. (±)-Aspidofractinine 23 was prepared by sequential reduction of 9. The model oxindolic methylketone 11, when reacted with acid, gave compounds 12 and 17a,b.

Url:
DOI: 10.1016/S0040-4039(00)99622-9


Affiliations:


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